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Mastery of Holcomb C3-R® Crosslinking for Keratoconus & Other Disorders: For Patients and Physicians

Brian S Boxer Wachler , Maxine Lipner

Medical / Clinical Medicine

Keratoconus is degeneration of the structure of the cornea. The cornea is the clear tissue covering the front of the eye. In keratoconus, the shape of the cornea slowly changes from round to conical (PubMed Health). In the early stages, keratoconus can be corrected with the use of lenses, but in the later stages, surgery is the only option.

Holcomb C3-R® is a non-surgical technique that involves placing drops of the vitamin Riboflavin into the eye and using a UV light to activate them. The drops strengthen the fibres of the cornea and over time, preserve sight (American Keratoconus Association).

This book is a concise guide to the technique of Holcomb C3-R® to treat keratoconus. Authored by the inventor of the procedure, Brian S Boxer Wachler, the text is based on his first hand clinical experience and explains the history and basic science of cross linking, the development and naming of the technique, its uses and complications, and first patient results.   


Key points

  • Concise guide to technique of Holcomb C3-R® to treat keratoconus
  • Authored by inventor of the technique and based on clinical experience
  • Includes more than 60 full colour images and illustrations
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