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Clinical Pharmacokinetics of Clavulanic Acid, a Novel β- Lactamase Isolated from Streptomyces Clavuligerus and Its Variability
Anab Fatima , Farah Khalid , Hina Zahid , Ishart Younus , Muhammad Jiyad Shaikh , Sheikh Abdul Khaliq
The clavulanic acid derived by fermentation of Streptomyces clavuligerus and possessed the capability to inactivate a broad range of Œ≤-lactamase enzymes. A complex physicochemical process involves the binding of clavulanic acid to Œ≤-lactamases in which clavulanic acid itself deplete irreversibly along with Œ≤-lactamase enzyme rendering amoxicillin spared which otherwise would hydrolyze by an enzyme. It is therefore termed as ,Äòsuicide ,Äòinhibitor for Œ≤-lactamases. We discussed here pharmacokinetic parameters and identified factors responsible for the variability of absorption of clavulanic acid. The results based on individual plasma concentration-time curve of amoxicillin and clavulanic acid in an open, randomized, two-way crossover study involving 10 healthy male subjects administered with two amoxiclav formulations.
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